Alkaloid profiling, anticholinesterase activity and molecular modeling study of Galanthus elwesii

Revised NMR data for incartine: an alkaloid from Galanthus elwesii.

Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine. The NMR data given previously for incartine were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. In vitro studies on the bioactivity of incartine were carried out.

Molecular docking study of Papaver alkaloids to some alkaloid receptors

Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine. Opioid alkaloids produce analgesia by affecting areas of the brain that have peptides with pharmacological pseudo-opioid properties. These alkaloids show important effects on some intracellular peptides l...

Sustainable Use of Various Amaryllidaceae Plants against Alzheimer’s Disease

Alzheimer’s Disease (AD), a slowly progressive neuropsychiatric illness, principally characterized by memory deficits, has become the fourth leading cause of death in developed nations. Since the patients with AD suffer from marked reduction of cholinergic neuronal function resulting in a deficiency in acetylcholine (ACh) concentration in the brain, and these reductions are associated with impa...

Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.

The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhi...

Anticholinesterase activity of bufotenine.